Ebook Introduction to Population Pharmacokinetic / Pharmacodynamic Analysis with Nonlinear Mixed Effects Models
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Introduction to Population Pharmacokinetic / Pharmacodynamic Analysis with Nonlinear Mixed Effects Models
Ebook Introduction to Population Pharmacokinetic / Pharmacodynamic Analysis with Nonlinear Mixed Effects Models
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Review
“This book may make the “User Guide V experience” a story from the good old times for the next generation of pharmacometricians.” (CPT: Pharmacometrics & Systems Pharmacology, 22 December 2014)
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From the Back Cover
A Guide to the Most Powerful Tool for Population Pharmacokinetic / Pharmacodynamic Analysis Population pharmacokinetic / pharmacodynamic analysis using Nonlinear Mixed Effects Modeling (NONMEM) is an approach that has gained substantial importance in pharmacometrics. NONMEM is the primary tool employed and is the keystone in novel initiatives on quantitative model-based drug development led by the US FDA, professional organizations, and the pharmaceutical industry This book uses a hands-on approach to introduce all aspects of NONMEM, how to use the system, and the concepts behind specific methods. As a didactic tool, it gives the reader an overview and provides critical information, including: Fundamentals: Population model concepts and terminology Requisite concepts for using NONMEM: writing control streams, model building, and evaluation aspects Examples of nonlinear modeling concepts and estimation basics with discussion on Bayesian analysis and PK/PD modeling Guidelines on data set requirements and structures, interpretation of the output, simulation using NONMEM, and quality control of pharmacometric anlayses This book also features a supplementary website with datasets, programming code, and exercises and solutions to provide readers with a practical understanding of population modeling. The authors are leading scientists with real-world experience who bring their critical thinking and problem solving perspectives together in this user-friendly guidebook.
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Product details
Hardcover: 320 pages
Publisher: Wiley; 1 edition (July 8, 2014)
Language: English
ISBN-10: 9780470582299
ISBN-13: 978-0470582299
ASIN: 0470582294
Product Dimensions:
6.1 x 0.9 x 9.3 inches
Shipping Weight: 1.2 pounds (View shipping rates and policies)
Average Customer Review:
5.0 out of 5 stars
2 customer reviews
Amazon Best Sellers Rank:
#917,165 in Books (See Top 100 in Books)
I love this book. The authors clearly and concisely explain all the essential concepts needed to perform population pharmacokinetic modeling and simulation. Together with PLT Tools' manual, this book can guide anyone new to NONMEM to build the first population PK model.
Excellent book, I'm a “really beginner†into this sort of analytical tool. I tried to read others sources but obviously were a complex starting point.
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